MODOCM.O.D.O.C. stands for Mental Organism Designed Only for Conquest. M.O.D.O.C. was created by A.I.M., the secret scientific organization which specializes in creating high-tech weapons for sale.

After breaking out from the Vault, M.O.D.O.C. returned to his position as head of A.I.M.

Under MODOC's leadership, A.I.M. used Simon Williams as a test subject in their Ionic enhancement program.  The tests exceeded parameters when Thor's assault on their facility contaminated the system with his mystical lightning.  Simon Williams became the energy being known as Wonder Man, who has subsequently joined the Masters of Evil.

A.I.M. was hired by Hydra to make the Cosmic Cube.  A.I.M. accepted the commision, but returned the money and cancelled the contract when it was determined that the Cosmic Cube might actually work.  This betrayal prompted baron Von Strucker to declare all-out war with Hydra, which ultimately caused the fall of both organizations, and the capture of MODOC by SHIELD.